Aging, Geriatric Syndromes and Clonal Hematopoiesis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50+
SponsorWashington University School of Medicine
About this trial
In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.
Eligibility criteria
Qualifiers
At least 50 years of age.
Able to understand written and spoken English.
Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)
Disqualifiers
Inability or unwillingness to complete health questionnaire (with the exception of hip and knee replacement participants).
History of a recent (<30 days) acute viral illness.
Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy > 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.
Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.
Trial design
Treatments tested in this trial
- Cognitive Assessment
- Activities of Daily Living Questionnaire
- Instrumental Activities of Daily Living, subscale of the OARS
- Karnofsky Self-reported Performance Rating Scale
- Number of Falls
- Physical Health Section, subscale of the OARS
- MOS Social Activity Survey
- Unintentional Weight Loss
- Peripheral Blood Draw
- Buccal Swab
- Heart Health and Smoking History from BRFSS questionnaire
- Gait Speed
- Grip Strength
- Height and Weight measurements
- Blood pressure measurement
- Optional bone marrow biopsy
- Blood draw for trauma measurements
- Femur head donation
- Knee bone fragments
- Bone marrow aspirate
Treatment groups
2,000 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Washington University School of Medicine
Lead sponsor
Edward P. Evans Foundation
Collaborator
Source ClinicalTrials.gov