Prediction of preoperative endometrial biopsy: the evolution from hyperplasia to cancer, the prognosis and the risk of recurrence. Intelligence methods artificial risk will be used to redefine the current risk classes including our profile immuno-mutational to provide a more precise characterization and closer to the real prognosis of the patient.
Age > 18 years;
Histological diagnosis of endometrial hyperplasia, endometrioid adenocarcinoma of the endometrium, healthy endometrium in patients undergoing total hysterectomy for benign extra-endometrial disease;
Written informed consent (to the study and data processing), for the party's patients only prospective and/or in follow-up) For the retrospective cohort: availability of samples adequately stored at the biobank of the Institute and availability of data relating to follow-up (at least 2 years)
Comorbidities not controlled with adequate medical therapy;
Infections of the endometrial cavity (pyometra);
Synchronous cancer;
Neoadjuvant treatments;
Regina Elena Cancer Institute
Lead sponsor
University of Rome Tor Vergata
Collaborator
Casa Sollievo della Sofferenza-IRCCS, San Giovanni Rotondo
Collaborator
Universita degli Studi di Palermo
Collaborator