Airway Microbiome of Patients With Protracted Bacterial Bronchitis
ConditionProtracted Bacterial Bronchitis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 5
SponsorUniversity Hospital, Antwerp
About this trial
This project aims to assess the relationship between the microbiome and virome composition, the immune responses, and the respiratory health of children with protracted bacterial bronchitis (PBB). In addition, we aim to evaluate how the standard treatment with azithromycin interacts with the components of the microbiome, virome and immune biomarkers.
Eligibility criteria
Qualifiers
Children with PBB diagnosis according to case definition
Consent form signed by parents or legal guardians
Disqualifiers
Comorbidities (HIV, asthma, chronic obstructive pulmonary disease, diabetes)
Have had serious illnesses (meningitis, pneumonia, bacteremia, empyema, etc) in the previous three months, identified only at the time of enrollment.
Have chronic respiratory conditions at the time of enrollment (non-PBB bronchiectasis not caused by PBB, CF, allergy, etc.).
Having received mechanical ventilation.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
160 Participants
are grouped into 1 trial groupSponsors and collaborators
Source ClinicalTrials.gov