ALDH2 Genetic Testing in East Asian Community

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorNorthwestern University

About this trial

The goal of this clinical trial is to learn whether education plus genetic testing for ALDH2\*2 and ADH1B\*2 is feasible and acceptable and whether it influences modifiable health behaviors in East Asian American adults who experience alcohol flushing when they drink alcohol or have a family history of flushing. The main questions it aims to answer are:

1. Is providing education plus ALDH2\*2/ADH1B\*2 genetic testing feasible and acceptable in a clinical care context? 2. Does receiving genetic testing results plus education lead to changes in modifiable health behaviors compared with education alone? Researchers will compare education plus genetic testing (intervention arm) to education only (control arm) to see if adding genetic testing improves feasibility/acceptability and supports health behavior change.

Participants will:

1. Complete an education module about alcohol flushing and ALDH2/ADH1B 2. Be randomized to either: (A) Receive genetic testing for ALDH2\*2 and ADH1B\*2 with results disclosure, or (B) Receive education only. 3. Complete follow-up measures about feasibility, acceptability, and modifiable health behaviors

Eligibility criteria

Qualifiers

Age 18 or older

Self-identified as East Asian and/or East Asian American

Flush when they drink alcohol or have a family member who flushes when they drink

Able to read and speak English

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Genetic Test Results Return
  • Alcohol Flushing Education

Treatment groups

100 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Northwestern University

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator