AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-99
SponsorTechnical University of Munich
About this trial
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations.
Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.
Eligibility criteria
Qualifiers
Diagnosed heart failure with preserved ejection fraction
Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion)
Disqualifiers
Paroxysmal, long-persistent or permanent atrial fibrillation
Clinically unstable coronary artery disease or acute coronary syndrome
Physical and/or mental inability to perform exercise testing
Prior ablation therapy
Trial design
Treatments tested in this trial
- Exercise training
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov