A unique combinational treatment for cancer employing intratumoral diffusing alpha radiation emitter device with check point inhibitor for recurrent unresectable or metastatic Head and Neck Squamous Cell Carcinoma
Pathologically confirmed, metastatic, or recurrent unresectable squamous cell carcinoma of the head and neck.
Ability to provide tissue sample, either from an archive or undergo another biopsy to provide a fresh sample
Targetable lesion must be technically amenable for the DaRT seeds implantation
Brachytherapy indication validated by a multidisciplinary team
Previous treatment for metastatic disease (for recurrent unresectable disease, previous treatment is allowed given that 6 months had elapsed from completion of treatment for primary disease)
Patients with brain metastases
Combined Positive Scores (CPS) <1
Patients with known contraindications to radiotherapy