It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.
A histologically confirmed diagnosis of hepatocellular carcinoma
A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma
Received standard diagnostic and staging procedures as per local guidelines
Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
Lack of or inability to provide informed consent
Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma
Secondary liver cancer