The international multicenter registry aims to gather real-world data on patient outcomes and assess the procedural success and performance of various device occluders used in the transcatheter treatment of pediatric and adult patients with perimembranous ventricular septal defects (PmVSD).
Patients with perimembranous ventricular septal defects (PmVSD), as defined by 2D transthoracic echocardiography according to previously published classifications.
Defect size between 3 mm and <20 mm on the left ventricular side, as measured by 2D echocardiography.
Left-to-right ventricular shunt.
Age ≥3 months and body weight≥5 kg.
Eisenmenger physiology (pulmonary vascular resistance > 8 Wood units, nonreactive) with an exclusive right-to-left shunt.
Pre-existing complete heart block or high-risk proximity of the conduction system to the defect without prior pacemaker implantation.
Severe aortic or tricuspid valve disease requiring surgical or catheter-based intervention.
Pregnancy or planned pregnancy if the procedure involves X-ray exposure.