Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

ConditionsANOCA - Angina With Non-obstructive Coronary Arteries INOCA (Ischemia With Non Obstructive Coronary Artery Disease)

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorBaylor Research Institute

About this trial

This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.

Eligibility criteria

Qualifiers

Aged 18 or older

Patient being evaluated for ANOCA or INOCA

Clinical suspicion for angina

Patient should be able to comply with the protocol.

Disqualifiers

Existing coronary artery disease

Previous percutaneous interventions within the coronaries

Current use (within 48 hours) of long-acting nitrate therapies

Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)

Trial design

Treatments tested in this trial

Coronary reactivity testing with and without nitrates

Treatment groups

50 Participants

are divided into 1 treatment group

Sponsors and collaborators

Baylor Research Institute

Lead sponsor

Source ClinicalTrials.gov