Demonstrate the existence of neurodevelopmental alterations in organoids derived from samples of patients with bipolar disorder (BD) with a neurodevelopmental (ND) component, compared with patients with bipolar disorder (BD) without an ND component.
Presence of bipolar disorder according to DSM-5 criteria
Able to freely give and sign consent
Affiliated or beneficiary of a health insurance plan
Previous participants in the NEMO study (2022-A00353-40)
- Presence of a severe symptomatic or unstable physiological or medical condition (including pregnancy)
History of psychiatric illness (stable or not), schizophrenia or any other pathology likely to interfere with bipolar disorder
History of severe head trauma (GCS<8 at time of trauma)
Presence of a neurological disorder affecting central nervous system function