Anesthesia and perioperative Neurocognitive Disorders in the Elderly patients undergoing hip fracture Surgery platform trial (ANDES platform trial): A pragmatic multi-arm, adaptive, open label, multicenter randomized controlled platform trial to assess the effect of different enhance anesthesia technique in perioperative neurocognitive function, as compared to standard anesthesia care in the elderly patients undergoing hip fracture
Aged 65 years and older.
Patients with unilateral hip fracture (including femoral neck, femoral head, intertrochanteric and subtrochanteric fractures) are scheduled for surgical treatment.
American Society of Anesthesiologists (ASA) physical status IV or below.
The patients or family members provide written informed consent.
Patients with multiple trauma or fractures (excluding trauma that the researcher judges will not affect the patient's overall recovery, such as simple spinal compression fractures, mild soft tissue contusions, fractures of hands and feet, etc.);
Two or more anesthetic surgeries are required.
Petients with an obvious history of head trauma (such as loss of consciousness for more than 5 minutes, post-traumatic amnesia, etc.);
Patients who the researcher believes are unable to complete the assessment of primary outcome;
Second Affiliated Hospital of Wenzhou Medical University
Lead sponsor
Zhejiang Provincial People's Hospital
Collaborator
First Affiliated Hospital of Wenzhou Medical University
Collaborator
Ningbo No.2 Hospital
Collaborator
Ningbo No.6 Hospital
Collaborator
Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Collaborator
Taizhou Hospital
Collaborator
Affiliated Wenling Hospital of Wenzhou Medical University
Collaborator
Lishui Country People's Hospital
Collaborator
The Fifth Hospital Affiliated to Wenzhou Medical University/ Lishui Central Hospital
Collaborator
Jinhua Municipal Central Hospital
Collaborator
Dongyang People's Hospital
Collaborator
People's Hospital of Quzhou
Collaborator