Animal and Plant Proteins and Glucose Metabolism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-70
SponsorUniversity of Missouri-Columbia
About this trial
The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.
Eligibility criteria
Qualifiers
age: ≥21 and ≤70 years;
BMI: >24.5 and <32.5 kg/m2;
habitual protein intake <0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and
weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.
Disqualifiers
prediabetes or type 2 diabetes;
evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate <60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);
vegetarians or vegans;
intolerance or allergies to ingredients in the metabolic meal or intervention diet;
Trial design
Treatments tested in this trial
- High animal protein isolate
- High animal protein whole food
- High plant protein isolate
- High plant protein whole food
Treatment groups
100 Participants
are divided into 5 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov