Antibiotic Dosing in Geriatric Patients At the Emergency Department
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age75+
SponsorUniversity Hospital, Ghent
About this trial
In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.
Eligibility criteria
Qualifiers
Patients presenting at the emergency department and later on admitted to the geriatric department
Patient age 75 years or older
Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.
Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam)
Disqualifiers
Admission to other units than the geriatric department incl. the ICU.
Absence of informed consent
Known hypersensitivity to beta-lactam antibiotics
Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.
Trial design
Treatments tested in this trial
- Blood sampling
- Sputum sample
- Hemoculture
- Urine sample
Treatment groups
180 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov