Health Trials

Antibiotic Dosing in Pediatric Intensive Care

ConditionsPharmacokineticsAmoxicillin-clavulanatePiperacillin-tazobactamVancomycinTeicoplaninMeropenemCiprofloxacinAmikacin
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-16
SponsorUniversity Hospital, Ghent

About this trial

Pharmacokinetics of antibiotics in critically ill neonates, infants and children

Eligibility criteria

Qualifiers

patients admitted to the pediatric intensive care unit

patient age/weight : 1,8 kg-15 years

patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines

intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)

Disqualifiers

no catheter in place for blood sampling

absence of parental/patient consent

known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides

extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )

Trial design

Treatments tested in this trial

  • blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care
  • blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care.
  • blood sampling in patients receiving vancomycin as part of routine clinical care.
  • blood sampling in patients receiving teicoplanin as part of routine clinical care.
  • blood sampling in patients receiving meropenem as part of routine clinical care.
  • blood sampling and urine smapling in patients receiving ciprofloxacin as part of routine clinical care.
  • blood sampling in patients receiving amikacin as part of routine clinical care.

Treatment groups

640 Participants
are divided into 7 treatment groups

7

Treatment groups

See each treatment group below.

Sponsors and collaborators

University Hospital, Ghent

Lead sponsor

University Hospital, Antwerp

Collaborator

Queen Fabiola Children's University Hospital (HUDERF/UKZKF)

Collaborator

Source ClinicalTrials.gov