Apathy in Parkinson Disease TMS Study
ConditionParkinson Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-80
SponsorUniversity of North Carolina, Chapel Hill
About this trial
The goal of this clinical trial is to develop non-invasive brain stimulation targets for the treatment of apathy, or motivation problems, in Parkinson Disease.
The main questions the study aims to answer are:
1. Does transcranial magnetic stimulation change effort task performance in Parkinson's Disease patients? 2. Is there a link between brain signals and apathy?
Participants will
* complete questionnaires and assessments * perform an effort task * have their brain activity recorded (EEG) * receive non-invasive brain stimulation (TMS)
Researchers will compare two stimulation locations (experimental site and control site) to see if TMS of the experimental site has an effect on apathy. Participants will receive stimulation of both sites (during separate visits).
Eligibility criteria
Qualifiers
Diagnosis of idiopathic Parkinson Disease.
At least 5 years of symptoms.
On dopaminergic medication for Parkinson Disease.
Stable on dopaminergic medication and other medications which may influence apathy (such as selective serotonin re-uptake inhibitors, stimulant medications) for at least 4 weeks prior to first study visit and remain stable throughout the study period.
Disqualifiers
Inability to provide informed consent.
Inability to perform effort task (determined during the titration session).
Presence of dementia (Montreal Cognitive Assessment (MoCA) score < 21).
History of epilepsy or brain surgery.
Trial design
Treatments tested in this trial
- Transcranial Magnetic Stimulation (TMS)
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of North Carolina, Chapel Hill
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
Source ClinicalTrials.gov