Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMilitary Institute od Medicine National Research Institute
About this trial
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
Eligibility criteria
Qualifiers
Age ≥ 18 years.
Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation).
Ability to provide written informed consent.
For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure.
Disqualifiers
Age < 18 years.
Pregnancy or breastfeeding.
Advanced visual impairment in the study eye (visual aquity worse than counting fingers).
Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma).
Trial design
Treatments tested in this trial
- Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy
- Phacoemulsification With Intraocular Lens Implantation
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov