About this trial
The goal of this observational, retrospective, multicenter study is to characterize the arrhythmic burden and identify predictive factors for ventricular arrhythmias (VAs) in adult patients hospitalized for acute myocarditis (AM). The main questions it aims to answer are:
* What is the incidence of sustained ventricular arrhythmias during the index hospitalization in patients with acute myocarditis? * What clinical, biological, electrocardiographic, and imaging factors predict the occurrence of sustained ventricular arrhythmias during hospitalization and after discharge?
Researchers will compare patients who developed sustained VAs during hospitalization to those who did not, in order to identify independent predictors of arrhythmic events and develop a validated risk stratification score.
Participants' medical records from 2020 to 2024 will be reviewed to collect:
* Baseline demographic, clinical, biological, electrocardiographic, and imaging data at admission * In-hospital management strategies and outcomes, including mortality, cardiogenic shock, and heart replacement therapy * Long-term follow-up data including VA recurrence, sudden cardiac death, and development of cardiomyopathy, with censoring applied on January 1, 2026
Eligibility criteria
Qualifiers
Age ≥ 18 years
Hospitalization for acute myocarditis
Confirmation of the diagnosis of AM by at least one of the following: (1) Cardiac magnetic resonance according to the revised 2018 Lake Louise Criteria; (2) Endomyocardial biopsy according to the Dallas criteria with associated immunohistochemical and molecular criteria; (3) Cardiac computed tomography with compatible late iodine enhancement
Disqualifiers
Age < 18 years
Concomitant acute coronary syndrome
Trial design
Treatments tested in this trial
- Treatment of acute myocarditis
Treatment groups
Locations
Sponsors and collaborators
AZ Sint-Jan AV
Lead sponsor
University Hospital, Toulouse
Collaborator
Rennes University Hospital
Collaborator
University Hospital, Montpellier
Collaborator
University Hospital, Bordeaux
Collaborator
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Collaborator
Poitiers University Hospital
Collaborator