The ARTI-UP study evaluates whether daily consumption of a supplement made from artichoke by-products, rich in hydroxycinnamic acids (HCAs), in combination with an energy-restricted Mediterranean diet (erMeDiet), can improve glycaemic control, reduce insulin resistance and contribute to weight loss in subjects with overweight or obesity. In addition, it seeks to understand the biological mechanisms involved using omic techniques and to establish predictive biomarkers that will enable progress towards personalised nutrition strategies.
BMI between 25.0 and 35.0 kg/m²
HOMA-IR ≥ 2.5.
Adequate physical examination and vital signs or clinically irrelevant to the intervention (those not related to metabolic health).
Subjects must be able to understand and be willing to sign the informed consent form, and must comply with all study procedures and requirements.
Weight loss of more than 5% in the last 6 months prior to surgery.
Consumption of antibiotics in the 3 months prior to the intervention.
Subjects who are undergoing treatment for weight loss/body composition modification, use medication for weight loss or blood glucose control, or have had weight loss surgery.
Have a medical diagnosis of type 1 or type 2 diabetes.
Clinica Universidad de Navarra, Universidad de Navarra
Lead sponsor
University of Navarra
Collaborator
Hospital of Navarra
Collaborator