The study aims to systematically document the course of REM sleep behavior disorder (RBD) and investigate possible clinical and imaging biomarkers for disease progression and conversion risk to Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The study will use artificial intelligence to analyze imaging and develop a reliable method to predict and stratify patients approaching conversion to overt a-synucleinopathy. Participants will be clinically evaluated and 2 imaging procedures will be done.
Confirmed clinical iRBD diagnosis by movement disorder specialists according to the International Classification of Sleep Disorders
Written informed consent
Known diagnosis of PD or other neurodegenerative disorder
Unequivocal signs of parkinsonism on examination
Narcolepsy or other known causes of RBD
Moderate to severe obstructive sleep apnea