Hemodialysis patients with xerostomia are divided into 2 groups which are group A (start with artificial saliva containing cumin and ginger extract for 2 weeks, free periods 2 weeks, then placebo for 2 weeks) and group B (start with placebo for 2 weeks, free periods 2 weeks, then artificial saliva containing cumin and ginger extract for 2 weeks). Amount of saliva (g/min), xerostomia's questionnaire, Increase of saliva score, World Health Organization Oral Mucositis Grading Scale, acid and base of saliva, quality of life's questionnaire will measure before, after using the sample for 7 and 14 days.
Age more than 18 years
Hemodialysis patients with xerostomia (saliva flow rate less than 0.2 g/min)
Hemodialysed history more than 3 months
Be willing to participate in the study
Patients with sialolith or Sjogren's syndrome
Uncontrolled other diseases
Using artificial saliva for more than 2 weeks
Taking pilocarpine and cevimeline