This study examines how spinal cord stimulation (SCS) affects pain level and quality of life in patients experiencing chemotherapy-induced peripheral neuropathy (CIPN). CIPN is a nerve problem and one of the potential side effects of chemotherapy that causes pain, numbness, tingling, swelling, or muscle weakness in different parts of the body. CIPN usually begins in the hands or feet and gets worse over time. SCS is a type of therapy that has proven to be effective in treating numerous non-malignant pain disorders including failed back surgery syndrome, refractory angina, limb ischemia, complex regional pain syndrome, and diabetic peripheral neuropathy. SCS may also be useful in patients with CIPN. This study evaluates how SCS affects pain and quality of life in patients undergoing spinal cord stimulation for CIPN.
Adult patients greater than or equal to 18 years of age who have been clinically diagnosed with CIPN for greater than six months after stopping chemotherapy
Average pain intensity >= 5 on 11-point numeric rating scale (NRS) in the lower extremities at enrollment
Failed conventional medication management with at least two neuropathic pain medications
Have electrophysiological evidence of length-dependent peripheral neuropathy
Patient refusal to be included in study
Presence of lower limb mononeuropathy
History of lower limb amputation or ulceration
Presence of another painful condition that is unrelated to CIPN and that is not intended to be treated in this study