Assessing Habitual, Goal-Directed, and Pavlovian Influences in Alcohol Use Disorder

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorTechnische Universität Dresden

About this trial

The first aim of this study is to establish the role of maladaptive reliance on habits for impaired control in addiction, employing a novel task - the Action-Sequence-Task (AST), which assesses interference between habitual and goal-directed control. The AST, along with the developed computational model, will be employed to test whether participants with Alcohol Use Disorder (AUD) and control participants differ with respect to task performance and estimated model parameters. The investigators hypothesize stronger habitual behavior (increased habitual tendency) and an increased susceptibility to conflict between habitual and goal-directed control, measured as increased interference, are associated with AUD.

The second aim of the study is to understand whether Pavlovian-to-Instrumental Transfer (PIT) reflects more of a controlled, goal-directed process, or a more automatic, habitual process. The investigators will use the single-lever PIT task as it is an efficient tool for testing the interaction between Pavlovian cues and instrumental behavior, especially when they are in conflict. In these trials, top-down control must be allocated to successfully overcome the conflict, which may share some common underlying mechanisms with the arbitration between goal-directed and habitual behavior during conflict, as assessed by the novel AST. The third aim of the study is to investigate whether severely dependent AUD patients would show a stronger PIT effect compared to a control group, consistent with the investigators' previous findings.

Eligibility criteria

Qualifiers

18-65 years of age

AUD subjects only: meet 4 or more criteria for DSM-5 alcohol use disorder

Sufficient motor skills and visual acuity to use PC

Ability to consent to the study and complete the questionnaires

Disqualifiers

Lifetime diagnosis of DSM-5 bipolar disorder, schizophrenia or schizophrenia spectrum disorder

Current diagnosis of severe major depression according to DSM-5, or presence of suicidal intention

Pregnancy

Severe withdrawal symptoms

Trial design

Treatments tested in this trial

  • Pavlovian-to-instrumental transfer (PIT) paradigm
  • Action Sequence Task (AST)
  • Basic psychological assessment (interview)
  • Basic psychological assessment (questionnaires)
  • Neuropsychology tests

Treatment groups

180 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Technische Universität Dresden

Lead sponsor

Charite University, Berlin, Germany

Collaborator

Central Institute of Mental Health, Mannheim

Collaborator