Assessment Metabolic Flexibility in Middle-aged Individuals: The Nutritional Impact of Cheese Consumption
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-65
SponsorUniversity of Cagliari
About this trial
The aim of the study will be to evaluate the impact of consumption of meat and dairy products from extensive or intensive farming on apparently healthy individuals aged between 45 and 65 years, a stage of life associated with reduced metabolic flexibility and changes in lipid metabolism.
The study will analyze:
1. The transcription factor PPAR-α determined by the gene expression of PPAR-α in white blood cells, variations in circulating fatty acid metabolism, and the endocannabinoid system determined by circulating analysis of N-acylethanolamine (NAE), and 2-monoacylglycerols (2-MG); 2. Metabolic flexibility, determined by indirect calorimetry in fasting condition during an incremental exercise; 3. Body composition, determined by bioimpedance analysis, waist circumference, and waist-to-hip ratio.
Eligibility criteria
Qualifiers
45-65 years of age
BMI < 27
waist-to-hip ratio female<0.85; male < 0.98
Disqualifiers
metabolic diseases
Physical activity of competitive nature
Vegans and vegetarians
Intolerances and allergies to the foods under study
Trial design
Treatments tested in this trial
- kent'erbas cheese study
Treatment groups
105 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov