This prospective cohort study aims to investigate the relationship between intraoperative mean arterial pressure (MAP) variability and postoperative fatigue syndrome (POFS) in elderly patients (≥18 years) undergoing laparoscopic abdominal surgery. The main research question is:
Does the degree of intraoperative MAP fluctuation correlate with postoperative fatigue in elderly patients?
Eligible patients scheduled for elective laparoscopic abdominal surgery under general anesthesia will have their intraoperative blood pressure variability recorded (generalized average real variability, G-ARV), and postoperative fatigue and recovery will be assessed on postoperative days 1, 3, and 7 using the Christensen fatigue scale.
Age ≥ 18 years;
ASA physical status I-III;
Scheduled for elective laparoscopic abdominal surgery under general anesthesia.
Severe cardiac, hepatic, or renal insufficiency, or major neurological or psychiatric disorders;
Known allergy to drugs used during the study;
Participation in other clinical trials within the past 3 months;
Unable to complete the required questionnaires or assessments;
This study includes adult patients undergoing elective laparoscopic abdominal surgery at Lianyungang First People's Hospital. Participants will be monitored for intraoperative mean arterial pressure variability and postoperative fatigue. Patients must be capable of completing postoperative assessments on days 1, 3, and 7.
Cohort
Prospective
Not listed
Postoperative Fatigue (Christensen Score)
Primary outcome is the patient's fatigue level measured using the Christensen fatigue scale on postoperative days 1, 3, and 7. This scale evaluates overall fatigue severity including physical exhaustion, muscle weakness, and attention deficits after laparoscopic abdominal surgery.
Intraoperative Vasoactive Drug Use
Total dose of vasoactive drugs administered during surgery
Postoperative Recovery Quality (QoR-15 Score)
Postoperative recovery quality is assessed using the Quality of Recovery-15 (QoR-15) questionnaire on postoperative days 1, 3, and 7. The QoR-15 consists of 15 items, each scored from 0 (worst recovery) to 10 (best recovery). The total score ranges from 0 to 150, with higher scores indicating better postoperative recovery. Recovery quality can be categorized as excellent (136-150), good (122-135), moderate (90-121), and poor (0-89).
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