A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including recurrent implantation failure (RIF) after assisted reproductive technology (ART) (including IVF, ICSI and FET), recurrent pregnancy loss (RPL) after spontaneous conception, and RPL after ART.
3 consecutive pregnancy losses after spontaneous conception
3 consecutive pregnancy losses after assisted reproductive technology treatment (ART) including IVF, ICSI and FET
3 failed embryo transfers characterized by no achieved pregnancy (after 3 cycles with minimum 1 embryo transfer of a good-quality embryo in each cycle.)
Age <18 or >45 years
AMH <4.0 pmol/l unless donor egg in previous cycles
Significant uterine malformation
Known endometrial pathologies including intrauterine endometriosis, adenomyosis, hyperplasia or polyps