Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants

ConditionBronchiolitis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-12
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.

Eligibility criteria

Qualifiers

Infants <12 months

With bronchiolitis during RSV epidemic season

No chronic illness

No bronchiolitis medical history

Disqualifiers

Chronic respiratory illness

Medical history of bronchiolitis or newborn asthma

Treatment with immunosuppressants

Patient with no social security affiliation

Trial design

Treatments tested in this trial

  • Sampling

Treatment groups

120 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Assistance Publique - Hôpitaux de Paris

Lead sponsor

Infectious Diseases Models for Innovative Therapies center

Collaborator