Auditory Processing in DOC Patients
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorBDH-Klinik Hessisch Oldendorf
About this trial
This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe acquired brain injury. The study further examines the association between EEG markers of auditory processing and long-term functional outcome at 12 months.
Eligibility criteria
Qualifiers
Presence of a disorder of consciousness (Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State [MCS]), classified using the Coma Recovery Scale-Revised (CRS-R) based on three assessments conducted on at least two separate days
Age between 18 and 80 years
Written informed consent provided by the patient's legal representative
Preserved brainstem auditory evoked potentials (BAEPs) on at least one side
Disqualifiers
Ongoing sedation at the time of EEG assessment
Current treatment with medications known to significantly affect cortical functional state, including barbiturates, neuroleptics (antipsychotics), antiepileptic drugs, benzodiazepines, or comparable agents
Colonization with multidrug-resistant organisms requiring isolation precautions (e.g., 4MRGN)
Pregnancy
Trial design
Treatments tested in this trial
- Coma Recovery Scale-Revised (CRS-R)
- Electroencephalography (EEG)
Treatment groups
42 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov