About this trial
This study at UCLA Center for Health Sciences is testing whether the Autoimmune Protocol (AIP) diet can lower protein levels in the urine of people with IgA Nephropathy (IgAN), a common kidney disease that can lead to kidney failure. The AIP diet avoids foods that may cause inflammation (like dairy, grains, and sugar) for 8 weeks, then gradually reintroduces them over 4 months. We're enrolling 30 adults aged 18-65 with IgAN and protein in their urine to try this diet for 6 months. Participants will track their urine protein daily at home, keep a food log, and have monthly lab checkups, with support from a diet expert. The main goal is to see if the diet reduces urine protein by 20% or more, which could slow disease progression and reduce the need for treatments like dialysis. This exploratory study aims to find out if diet changes can help manage IgAN.
Eligibility criteria
Qualifiers
Age 18-65
Diagnosed with IgA Nephropathy (IgAN)
Active disease with urine protein/creatinine ratio ≥ 1
Stable ARB or ACE inhibitor for at least 1 month prior
Disqualifiers
Inability to comply with dietary or follow-up requirements
Participation in other interventional studies
Significant comorbidities interfering with study participation -
Trial design
Treatments tested in this trial
- Low inflammation diet intervention