This study at UCLA Center for Health Sciences is testing whether the Autoimmune Protocol (AIP) diet can lower protein levels in the urine of people with IgA Nephropathy (IgAN), a common kidney disease that can lead to kidney failure. The AIP diet avoids foods that may cause inflammation (like dairy, grains, and sugar) for 8 weeks, then gradually reintroduces them over 4 months. We're enrolling 30 adults aged 18-65 with IgAN and protein in their urine to try this diet for 6 months. Participants will track their urine protein daily at home, keep a food log, and have monthly lab checkups, with support from a diet expert. The main goal is to see if the diet reduces urine protein by 20% or more, which could slow disease progression and reduce the need for treatments like dialysis. This exploratory study aims to find out if diet changes can help manage IgAN.
Age 18-65
Diagnosed with IgA Nephropathy (IgAN)
Active disease with urine protein/creatinine ratio ≥ 1
Stable ARB or ACE inhibitor for at least 1 month prior
Inability to comply with dietary or follow-up requirements
Participation in other interventional studies
Significant comorbidities interfering with study participation -
Single group
Low inflammation diet intervention
BehavioralAutoimmune Protocol Diet intervention
Change from Baseline Urinary Protein to Creatine Ratio at 6months
Primary Outcome Measure 1\. Change in Urinary Protein-to-Creatinine Ratio * Description: This measure assesses the reduction in proteinuria, a key indicator of IgA Nephropathy (IgAN) activity, following the Autoimmune Protocol (AIP) diet intervention. The urinary protein-to-creatinine ratio (UPCR) will be calculated from spot urine samples collected at baseline and monthly intervals. The study aims to detect a reduction of 20% or greater from baseline, reflecting a clinically meaningful improvement in kidney function. * Time Frame: Baseline to 6 months (end of study). * Measurement: Expressed as grams of protein per gram of creatinine (g/g), analyzed via laboratory testing of urine samples.
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