This study evaluates the safety and preliminary efficacy of autologous bone marrow mononuclear cell transplantation combined with rehabilitation in children with neurological sequelae caused by hypoxic-ischemic brain injury or intracranial hemorrhage. Participants in the intervention group will receive autologous bone marrow aspiration, mononuclear cell transplantation via intrathecal route, and rehabilitation, while the control group will receive rehabilitation alone. Outcomes will be compared between groups over follow-up time points.
Children diagnosed with cerebral palsy
Age from 12 months to 72 months
Cerebral palsy caused by hypoxic-ischemic brain injury or intracranial hemorrhage
Gross Motor Function Classification System (GMFCS) level III to V
Children with acute infection at the time of screening or enrollment
Children with severe coagulopathy or contraindications to bone marrow aspiration
Children with severe systemic diseases (e.g., severe cardiac, hepatic, or renal failure)
Children with contraindications to anesthesia or intrathecal transplantation procedures