Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age35-70
SponsorUniversity of Minnesota
About this trial
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.
Eligibility criteria
Qualifiers
Aged 35-49 or 50-70 years of age who experienced premature (<40) or early (≤45) menopause
Premenopausal 35-49 years of age
Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of >30 mIU/mL
Disqualifiers
Current nicotine/tobacco use within the past six months
Are diabetic or asthmatic
Have diagnosed significant carotid stenosis
Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
Trial design
Treatments tested in this trial
- Microneurography to measure muscle sympathetic nerve activity (MSNA)
- Baroreflex sensitivity testing
- Sympathoexcitatory Maneuvers
- Blood tests
Treatment groups
160 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov