Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia. Conclusive evidence for patients with AHRF without COVID-19 is still missing. The investigators hypothesis that awake prone position in patients with AHRF is superior to standard supine/semi-recumbent position in terms of reducing the rate of tracheal intubation and/or all-cause death within 28 days after randomization.
Patients in the intensive care unit
High possibility of Pneumonia (community-acquired pneumonia or hospital-acquired pneumo-nia) either diagnosed by chest x-ray or computed tomography or clinically diagnosed at least with one of the following signs
Appearance of purulent secretions or changes in characteristics (color, odor, quantity, consistency)
Cough or dyspnea or tachypnea
Age below 18
Pregnant woman
Patient is unlikely/unable to awake prone positioning, or to be compliant as indicated by the treating team
Prolonged need (≥ 4 days) for HFNO, NIV or CPAP before study inclusion
Universitätsklinikum Hamburg-Eppendorf
Lead sponsor
Charite University, Berlin, Germany
Collaborator
Asklepios Kliniken Hamburg GmbH
Collaborator
University Hospital Tuebingen
Collaborator
University Hospital Heidelberg
Collaborator
Klinikum Würzburg Mitte gGmbH, Missioklinik
Collaborator
Elisabeth-Krankenhaus Essen
Collaborator
Hannover Medical School
Collaborator
Universitätsklinikum Freiburg
Collaborator
Krankenhaus Barmherzige Brüder, Regensburg
Collaborator
Technical University of Munich
Collaborator
Klinikum Nürnberg
Collaborator
RWTH Aachen University
Collaborator
Lung Clinic Hemer
Collaborator
University of Leipzig
Collaborator
Wuerzburg University Hospital
Collaborator
University Hospital Erlangen
Collaborator
University Hospital Schleswig-Holstein
Collaborator
Klinikum Hanover-Siloah Hospital
Collaborator
Ludwig-Maximilians - University of Munich
Collaborator
Bielefeld University
Collaborator