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Bilogical Assesment During Intrusion of Lower Incisors

ConditionOrthodontic Treatment Efficiency
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age14-18
SponsorAl-Azhar University

About this trial

biological assesment during intrusion of lower incisors

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients requiring extraction-based orthodontic treatment

Presence of deep overbite requiring lower incisor intrusion

Age range: 18-30 years

Good general health

Disqualifiers

Systemic diseases affecting bone metabolism

Previous orthodontic treatment

Periodontal disease

Smoking

Trial design

Design model

Parallel

Treatments tested in this trial

  • Corticision

    Other intervention

    1. Prior panoramic x-ray or serial periapical x-rays are essential to assure the availability of interradicular room to carry out the procedure. 2. Preoperative antiseptic mouthwash is administered to prevent potential infections. 3. Infiltration anesthesia is applied. 4. A reinforced 15T scalpel is positioned on the interradicular attached gingiva at an inclination of 45-60 degrees on the long axis of the tooth to be moved.

Treatment groups

16 Participants
are divided into 2 treatment groups
Group A: controlledNo intervention 0 interventions
Group B: active groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Gingival crevicular fluid (GCF) prostaglandin E2 (PGE2) levels measured by enzyme-linked immunosorbent assay (ELISA) (pg/mL)

GCF samples will be collected from lower incisors using microcapillary tubes at baseline and during follow-up visits. Prostaglandin E2 levels will be quantified using ELISA kits and expressed in pg/mL to assess the biological response to corticision-assisted intrusion.

Time frame
12 weeks

Secondary outcomes

1

Amount of lower incisor intrusion measured in millimeters (mm) using cone beam computed tomography (CBCT)

CBCT imaging will be used to measure the vertical displacement of lower incisors in millimeters by comparing pre- and post-treatment positions.

Time frame
12 weeks
2

External apical root resorption measured in millimeters (mm) using cone beam computed tomography (CBCT)

CBCT imaging will be used to assess external apical root resorption by comparing root lengths before and after treatment.

Time frame
Time Frame: 12 weeks

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Al-Azhar University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: