Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorIstituto Auxologico Italiano
About this trial
The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are:
* Which set of biomarkers explain genotypic-phenotypic correlations in ALS? * Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups?
Participants will undergo:
* neurological evaluation * neurophysiological evaluation * neuropsychological evaluation * whole exome sequencing * biomarker measurement in CSF and plasma
Eligibility criteria
Qualifiers
diagnosis of ALS or other motor neuron disease
residence near the study centers
Disqualifiers
refusal to participate to the study
unable/unwilling to perform follow-up visits
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Sponsors and collaborators
Istituto Auxologico Italiano
Lead sponsor
A.O.U. Città della Salute e della Scienza
Collaborator
Ospedale San Raffaele
Collaborator
Source ClinicalTrials.gov