Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMassachusetts General Hospital

About this trial

In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.

Eligibility criteria

Qualifiers

18 years and older

NT-proBNP > 125 pg/mL

BNP > 35 pg/mL

Capillary wedge pressure ≥ 15 mmHg on right heart catheterization or CI <2.8 L/min/m2

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

3,000 Participants
are grouped into 3 trial groups

Sponsors and collaborators

Massachusetts General Hospital

Lead sponsor

Roche Diagnostics GmbH

Collaborator