Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30-85
SponsorZhongshan Ophthalmic Center, Sun Yat-sen University

About this trial

The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.

Eligibility criteria

Qualifiers

Glaucoma patients eligible for standalone or combined angle intervention surgeries, such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgical iridectomy or phacoemulsification and intraocular lens implantation;

Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other optical biometry);

Patients willing to participate in this study, signing informed consent, and agreeing to follow-up according to the study protocol.

Disqualifiers

Patients with severe ocular conditions such as corneal infection, ulcer, trauma, ocular tumors, retinal vascular occlusion, and retinal detachment;

Those with various types of eye diseases that affect ocular parameter acquisition or interfere with visual field examination;

Long-term local or systemic use of glucocorticoids;

Patients with severe systemic diseases;

Trial design

Treatments tested in this trial

  • various types of angle interventions

Treatment groups

300 Participants
are divided into 5 treatment groups