"Blood and Tissue Extraction for Immunological Examinations During Neoadjuvant Therapy of Soft Tissue Sarcoma" is a prospective study with additional translational research using preoperative and postoperative tissue, blood sampling and advanced imaging.
Planned histological confirmation for especially high-risk soft tissue sarcoma via open Sampling
Indication for neoadjuvant multimodal therapy (radiation and locoregional Hyperthermia, optionally with simultaneous chemotherapy)
Planned resection of a department of the CWS
Age > 18 years
Age < 18 years
Poor understanding (language etc.)
Lack of reconnaissance ability
Single group
Blood and tissue collection for immunological studies, advanced imaging.
Other interventionBlood and tissue collection for immunological studies under neoadjuvant Therapy of soft tissue sarcomas. Prospective data collection and translational accompanying research on standard therapy. Use of tissue, blood samples and advanced imaging.
neoadjuvant Therapy
Other interventionneoadjuvant Therapy
Description of the cellular immune status via flow-cytometrie from collected blood samples
Blood samples are taken on the days of simulation-CT, first and third week of the radiation therapy, as well as before surgery.
Description of the cellular immune status on tissue samples ussing komplex immunohistochemie
Tissue samples are taken as incisional biopsie as well as in the tumor tissue after the surgery
Measurement of the cellular free DNA from collected blood samples
Blood samples are taken on the days of simulation-CT, first and third week of the radiation therapy, as well as before surgery.
Measurement of HMGB1 from collected blood samples
Blood samples are taken on the days of simulation-CT, first and third week of the radiation therapy, as well as before surgery.
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