This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.
Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria,
in Hoehn and Yahr stage 2-4,
a score of ≥23 on the mini-Mental Scale Examination.
History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis;
Ankle branchial index ≤ 0.9 or > 1.3.
History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy.
History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment.
The University of Texas Health Science Center at San Antonio
Lead sponsor
National Institute on Aging (NIA)
Collaborator