Blood Lipid Responses to Diet Macronutrients
ConditionNutritional and Metabolic Diseases
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Oxford
About this trial
The macronutrient composition of a diet (proportions of carbohydrates, fats and proteins) strongly influences the way the body stores and utilises substrates (e.g., fats and sugars), which in turn influences the risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the risk of cardiometabolic disease is unknown.
In a randomized, parallel design, this study will investigate how the overconsumption of carbohydrates and fats affects blood lipid responses and liver metabolism in adults free from metabolic disease. By genotyping participants, the interaction between macronutrient content and an individual's genes on blood lipid responses and liver metabolism will be examined.
Eligibility criteria
Qualifiers
Participant is willing and able to give informed consent for participation in the study.
Male or Female, aged ≥18 to ≤65 years
Body mass index (BMI) ≥19 to ≤35 kg/m2
No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism.
Disqualifiers
Aged <18 or >65 years
BMI <19 or >35 kg/m2
A blood haemoglobin <135 mg/dL for men and <120 mg/dL for women
Donated (or lost) ≥250 mL of blood in the previous two months
Trial design
Treatments tested in this trial
- Diet
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov