About this trial
Food allergies are now a major problem. These experiments involve getting blood from people with food allergies and from people without food allergies. The blood collected will be used to answer questions and find information about peanut and other food allergies.
Samples will come from:
* People signed up by the investigators at the University of Colorado Denver * University of North Carolina, Massachusetts General Hospital, Children's Hospital of Colorado and the Immune Tolerance Network (Benaroya Research Institute) where people have been treated for peanut allergies * University of North Carolina, Massachusetts General Hospital, National Jewish Health and The Children's Hospital in Denver where people have taken part or will take part in clinically indicated oral food challenges.
Blood and health histories from the University of North Carolina, Massachusetts General Hospital, National Jewish Health, The Children's Hospital and the Immune Tolerance Network will not have personal information linked.
The specific aims of this experiment are:
1. Come up with a lab test that will predict how bad an allergic reaction will be to peanuts. 2. Find out what part of a peanut causes allergic reactions. 3. Come up with preventions that can block peanut allergies. 4. Find the strongest proteins in walnuts.
Eligibility criteria
Qualifiers
De-identified sera or plasma from patients who have undergone Oral ImmunoTherapy (OIT) for peanut allergy. These samples already exist.
patients have been enrolled in a controlled trial of OIT for peanuts, and had at least one oral challenge.
Age 1-75.
De-identified samples from patients who are undergoing clinically indicated food challenges for peanut allergy.
Disqualifiers
Any known significant medical or psychiatric diagnosis
Use of an investigational drug within 30 days
Use of omalizumab (anti-IgE; Xolair) within 6 months
Trial design
Treatments tested in this trial
- Not listed
Trial groups
Sponsors and collaborators
University of Colorado, Denver
Lead sponsor
National Institutes of Health (NIH)
Collaborator