About this trial
The goal of this study is to compare two different ways of dosing cefepime, an antibiotic for very sick patients - the usual approach to dosing or a new dosing method. The new dosing method uses only doses that are available in normal care, but choosing between the different doses is based on more information about the patient's body including their kidney function. The primary purpose of this study is to test how easy it is for healthcare professionals to use the new dosing method and how best to conduct the trial. The study will also assess if the new dosing method helps patients recover faster and reduces side effects.
Eligibility criteria
Qualifiers
Adults ≥18 years of age
Admitted to one of the ICUs at the study center
Prescribed cefepime therapy by the care team
Disqualifiers
Individuals will be those with a cephalosporin allergy
Received >1 dose of cefepime in the 24 hours before ICU admission
Transferred from an external hospital without compatible EHR
Does not have a cystatin C and a creatinine available for drug dosing
Trial design
Treatments tested in this trial
- Up-front individualized dosing algorithm
- Usual Care