Bone Density and Vascular Calcifications Evolution After Renal Transplant

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Liege

About this trial

The investigators project is based on:

* Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA); * The non-invasive detection of vascular calcifications (by abdominal CT scanner) and bone abnormalities associated with kidney transplantation, as well as the analysis of evolution over time; * Longitudinal evaluation of nephrological clinical parameters (glomerular filtration rate, number and type of rejections, immunosuppressive medications) as well as biological and urinary parameters of mineral metabolism (parathormone, sclerostin, bone alkaline phosphatase) depending on the type and severity of bone abnormalities; * The evaluation of these nephrological clinical parameters and of the biological parameters of mineral metabolism depending on the extent and evolution of vascular calcifications but also on bone morphology; * The study of possible relationships between bone mass and muscle mass (and functioning)

Eligibility criteria

Qualifiers

At least 18 years old

Recent kidney transplant patients (<3 months)

Medical history available

Biological parameters of the past year available

Disqualifiers

Treatment with bisphosphonate, RANKL inhibitor or SERM with bone action in the last 3 months before the transplant

Multiple organ transplant patients

Trial design

Treatments tested in this trial

  • High-resolution peripheral quantitative CT scanner (HRpQCT)

Treatment groups

No treatment groups listed

Sponsors and collaborators