Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age55-75
SponsorLoughborough University
About this trial
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause. Bone mass and structure can be assessed by scans.
Antiresorptive medications are commonly prescribed to reduce bone resorption, preventing further bone loss and thus reducing the possibility of fracture. Exercise can also benefit bone mass and structure but current evidence do not show whether exercise is more, or less, effective in combination with antiresorptive medication.
This study will compare the effect of a brief, home-based exercise programme on bone mineral and structural properties in women taking/ not taking antiresorptive medication.
Eligibility criteria
Qualifiers
Women aged 55-75 years old
>4y since menopause/hysterectomy/oophorectomy.
Baseline femoral neck or lumber spine BMD T-score between -1 and -3.
Able to complete the hopping exercises.
Disqualifiers
Body mass index (BMI) >35 kg/m2
Any medical condition, surgery, or injuries that contraindicate exercises including lower limb or back pain, knee or hip osteoarthritis.
Vertebral fracture or multiple low trauma fractures (recent expert consensus recommends lower impact exercise for these groups)
Replacement of hip joint(s)
Trial design
Treatments tested in this trial
- EXERCISE TRAINING
- Antiresorptive medication (routine clinical care)
Treatment groups
110 Participants
are divided into 2 treatment groupsSponsors and collaborators
Loughborough University
Lead sponsor
University of Sheffield
Collaborator
University of Cambridge
Collaborator
Source ClinicalTrials.gov