The aim of this study is to investigate whether the activity in brain areas controlling the bladder is different among children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the aim is to investigate if sacral transcutaneous electric nerve stimulation (TENS) has a central mechanism of action. Children with OAB and DUI will be recruited from involved pediatric departments, and functional magnetic resonance imaging (fMRI) will be performed before and after 10 weeks of sacral TENS. In healthy children without bladder symptoms, only the baseline fMRI will be performed.
Overactive Bladder as per International Children's Continence Society criteria (cases only).
At least 2 incontinence episodes per week (cases only).
No urinary tract symptoms (healthy participants only).
More than 3 daily urinations.
Known urogenital abnormality affecting the lower urinary tract function.
Prior surgery in the urinary tract (except circumcision).
Known neurological diseases or prior cerebral surgery.
Known neuropsychiatric disorders or suspicion of those by screening.
Aalborg University Hospital
Lead sponsor
Aarhus University Hospital
Collaborator
Regional Hospital West Jutland
Collaborator
Regionshospital Nordjylland
Collaborator