Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment. Such deficits-including declines in memory, learning, processing speed, and executive function-reduce daily living abilities and increase risks of falls and depression.
Functional near-infrared spectroscopy (fNIRS) enables real-time monitoring of oxygenated and deoxygenated hemoglobin fluctuations, reflecting brain network function. This study aims to identify affected neural network regions in anemic patients and visualize connectivity changes using heatmaps and arc-based mapping. The findings will support early detection of cognitive impairment and guide precise clinical interventions, ultimately informing individualized treatment strategies to enhance therapeutic outcomes and quality of life.
Diagnosis of anemia
First hospitalization
Male or female, aged 18-65 years
Willing and able to comply with the requirements for this study and written informed consent
History of psychiatric illness
History of severe brain disease
Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study
Institute of Hematology & Blood Diseases Hospital, China
Lead sponsor
Tianjin University
Collaborator