The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa. The overarching goal of this trial is to use a novel virtual reality (VR) based intervention that simultaneously engages physical and cognitive activity aimed at improving brain health and cognition in older adults. The investigators will compare 3 types of interventions: physical activity, VR cognitive activity, and combined VR physical and cognitive activity over 16 weeks to evaluate physical and brain health changes.
50-85 years of age
Fluent in English
Can safely ride a stationary bike
Dementia
History of a neurological disorder
Severe sensory deficits
Inability to perform intervention (e.g., inability to cycle safely)
Factorial
Physical Activity
BehavioralThere will be three sessions a week over the course of 16 weeks.
Cognitive Activity (VR)
BehavioralThere will be three sessions a week over the course of 16 weeks.
Physical and Cognitive Activity
BehavioralThere will be three sessions a week over the course of 16 weeks.
MST memory performance
With the study's primary focus on hippocampal function, we will use the Mnemonic Separation Task (MST), a hippocampus-dependent discrimination test of similar objects, as our primary cognitive outcome. The MST is a memory task designed to heavily tax memory processes for making fine discriminations between highly similar objects or unrelated objects.
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