The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
Acute cerebral lesion with a Glasgow Coma Scale <13 needing admission in ICU and mechanical ventilation with tracheal intubation for neurological cause : cerebrovascular stroke either ischemic or hemorrhagic including aneurysmal subarachnoid hemorrhage, traumatic brain injury, anoxo ischemic encephalopathy after cardiac arrest or brain tumour
Mechanical ventilation more than 48 hours
18 to 75 years old
Neurological stability with no intracranial hypertension with minimal sedation
Posterior cranial fossa lesion
Admission for status epilepticus or central nervous system infection
Spinal cord injury (tetraplegia or paraplegia)
Uncontrolled status epilepticus or uncontrolled central nervous system infection
University Hospital, Clermont-Ferrand
Lead sponsor
ANARLF Network
Collaborator
Direction Générale de l'Offre de Soin (DGOS)
Collaborator