Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
ConditionNicotine Dependence
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-55
SponsorUniversity of Southern California
About this trial
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes. This within-subject, repeated-measures study will evaluate the acute effects of a single 6 mg oral nicotine pouch on subjective craving and prefrontal neural responses to smoking-related cues using functional near-infrared spectroscopy (fNIRS). Participants will complete assessments before and after nicotine pouch administration following overnight nicotine abstinence to characterize changes in craving and neural cue reactivity.
Eligibility criteria
Qualifiers
Age 21 years - 55 years
Self-reported use of cigarettes within the past 30 days
Fagerström Test for Nicotine Dependence (FTND) score ≥5, indicating moderate to high nicotine dependence
Fluent in English
Disqualifiers
Age younger than 21 years or older than 55 years
Expressed intent to reduce or quit nicotine use within the next 30 days
History of medical conditions contraindicated for nicotine use (e.g., uncontrolled hypertension, recent cardiac events)
Primary use of non-cigarette products (e.g., cigars, pipe tobacco, smokeless tobacco)
Trial design
Treatments tested in this trial
- Oral Nicotine Pouch
- Smoking Cue Reactivity Task
Treatment groups
45 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov