This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic. The aim is to better understand how individuals recover from TBE, which symptoms may persist after the infection, and which patients may require additional support during their recovery. Participants are examined several times after hospital discharge (at 2-4 weeks, 3 months, 6 months, and 12 months) to observe changes in symptoms, functional status, and daily activities. Follow-up assessments include evaluation of common post-infection problems such as tiredness, headaches, memory or concentration difficulties, sleep issues, or limb weakness. Symptoms lasting for several months are categorized as post-encephalitic syndrome (PES).
The study also assesses how TBE affects daily functioning, school and work performance, and overall quality of life using questionnaires and short functional assessments. In addition, the study includes a public-health component that estimates the broader impact of TBE in the population and evaluates the potential benefits of vaccination in preventing long-term health complications.
The findings aim to support improved patient care, follow-up planning, and evidence-based public-health decision-making in the Czech Republic.
Hospitalization due to suspected central nervous system (CNS) infection.
All age groups (children and adults).
Ability to participate in scheduled follow-up (in person or via telephone).
Informed consent provided by the patient or legal guardian (for minors).
Alternative diagnosis explaining the CNS symptoms
Missing essential clinical or laboratory data required to confirm TBE or assess outcomes.
Refusal or inability to provide informed consent.
Inability to complete follow-up assessments, including situations where reliable contact cannot be maintained.
Charles University, Czech Republic
Lead sponsor
České Budějovice Hospital
Collaborator
University Hospital Ostrava
Collaborator
Hospital Pardubice
Collaborator
Bulovka Hospital
Collaborator