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Can Exercise Ameliorate Immunosenescence and Thereby Reduce Relapse in Head and Neck Cancer Patients

ConditionsAgingHigh-intensity Interval TrainingHead and Neck Cancers - Tonsils
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-80
SponsorChang Gung Memorial Hospital

About this trial

Through the implementation of this three-year project, investigators expect to find a safe and effective exercise prescription for patients with oral cancer after surgery. The findings will encourage and promise and add further support to the concept that exercise prescription is worth implementation as part of care for the patients with head and neck cancer.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥20

Pathology:Squamous cell carcinoma

Need CCRT treatment

ECOG PS<2

Disqualifiers

ECOG PS≥2

Unable to tolerate basic exercise, or CCRT treatment

Mental illness or any medical illness or concurrent illness that may be aggravated by exercise training or unmanageable

Any medical condition that unsuitable for exercise

Trial design

Design model

Parallel

Treatments tested in this trial

  • HIIT & Record of physical activities at home.

    Other intervention

    After CCRT treatment 4-5 week arrange HIIT excise for patient two to three times a week 24-36 times. And record of physical activities at home. According to the record set goal to acheive.

  • HIIT only

    Other intervention

    After CCRT treatment 4-5 week arrange HIIT excise for patient two to three times a week 24-36 times.

Treatment groups

180 Participants
are divided into 2 treatment groups
Group A: Head and Neck patient after CCRT treatment with HIIT trainingExperimental treatment 2 interventions
Group B: Head and Neck patient after CCRT treatmentNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

% of participants with phenoage and age

To evaluate the phenoage acceleration by calculating differencehe of patients with phenoage and age.

Time frame
1 month, after CCRT
2

% of participants with phenoage and age

To evaluate the phenoage acceleration by calculating differencehe of patients with phenoage and age.

Time frame
6 month, after CCRT
3

Peak VO2 (ml/min/kg) of participants

To record the Peak VO2 (ml/min/kg) of participants and to evulate the effectiveness of exercise training

Time frame
baseline
4

Peak VO2 (ml/min/kg) of participants

To record the Peak VO2 (ml/min/kg) of participants and to evulate the effectiveness of exercise training

Time frame
1 month, after CCRT

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Chang Gung Memorial Hospital

Lead sponsor

Source ClinicalTrials.gov
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