Cannabinoids for Osteoarthritis Pain Effectiveness Trial
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-80
SponsorUniversity Health Network, Toronto
About this trial
This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians. Current OA treatments often have limited effectiveness and may cause side effects. As a result, many individuals with OA turn to medical cannabis for pain relief, despite limited scientific evidence supporting its efficacy.
The goal of this study is to assess the feasibility of a larger trial evaluating the effects of two cannabis compounds-CBD and THC-compared to a placebo (a look-alike substance containing no active drug) on pain interference in patients with hip and/or knee osteoarthritis.
Participants will:
* Take either CBD, THC, or a placebo capsule daily for 8 weeks * Complete follow-ups remotely, with no in-person clinic visits required * Maintain a diary tracking their study drug usage and any additional pain medications
Eligibility criteria
Qualifiers
Age 40-80 years
Diagnosed with hip and/or knee osteoarthritis as per the American College of Rheumatology criteria
Experiencing moderate to severe pain interference as indicated by a PROMIS-PI SF-6a T-score ≥ 60
Have not initiated any new analgesics or osteoarthritis treatments in the previous 4 weeks
Disqualifiers
Hip or knee surgery planned in the coming 4 months,
Injection into the affected joint(s) within the past 3 months (e.g., cortisone, plasma-rich protein, etc.),
Planned injection into the affected joint(s) during trial period,
Inflammatory arthritis (e.g., rheumatoid arthritis, Psoriatic arthritis, gout, etc.),
Trial design
Treatments tested in this trial
- CBD
- THC
- Placebo
Treatment groups
100 Participants
are divided into 3 treatment groupsSponsors and collaborators
University Health Network, Toronto
Lead sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator
Source ClinicalTrials.gov